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Our StudiesMyClimb

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For more information about Tenaya’s clinical programs, complete this form or contact Wendy on our Patient Advocacy team by email or phone at (650) 825-6990 option 4. THIS WEBSITE IS INTENDED FOR U.S. AUDIENCES ONLY.

Wendy Borsari, Associate Director of Patient Advocacy, Living with genetic HCM, community advocate for over a decade

MyClimb is a natural history study designed to collect and evaluate information on the course of cardiomyopathy in infants, children and teens with the MYBPC3 genetic mutation.

Natural history studies track the course of a condition over time, identifying demographic, genetic, environmental, and other factors that may impact progression and outcomes. No investigational treatments are administered as part of a natural history study.

The data from a natural history study will inform the development and clinical trial design of potential new treatments, including gene therapies.

Who can take part in the MyClimb study?

People 18 years and younger who have the MYBPC3 gene mutation and symptoms of HCM may be eligible for the MyClimb study.

Study staff will evaluate people interested in taking part in MyClimb and determine if they are eligible. These are not all of the eligibility criteria for this study.

What is the purpose of the MyClimb study?

This study has been carefully designed to collect data such as people’s medical information, family history, and other related information that will provide researchers with more information about the condition and the MYBPC3 genetic mutation. The MyClimb study will enroll approximately 300 participants at about 40 sites worldwide.

Participation in the MyClimb study is entirely voluntary. There is no cost to participate in this study.

What to expect in the MyClimb study

During the five-year study, researchers will gather data to help evaluate the disease course, burden of illness, risk factors, and biomarkers (measurable characteristics of HCM such as protein levels in the blood) associated with disease progression.

Two types of information will be gathered for each participant:

Prospective
(collected during participant visits)

Data will be collected during the participant’s usual visits to the study doctor’s office from time of enrollment for up to 5 years.

Retrospective
(collected from medical chart information)

Information that has already been collected as part of past doctor’s visits. This study will look at data in medical charts collected up to 10 years ago.

For the prospective part of the study, data will be collected as part of regularly planned doctor visits and recorded by a cardiologist or nurse.

These visits will include the typical tests that are conducted as part of a regular office visit, with additional study-related activities, such as:

Filling out quality-of-life questionnaires (surveys) throughout the study

The surveys may include questions about heart health, emotional and physical wellbeing, and how often a person may feel a certain way.

Blood tests conducted by the doctor’s office staff

The study will not require any extra visits with a participant’s doctor. Participation is entirely voluntary, and participants are free to leave the study at any time without impact to routine care.

Will there be identifying information included in the collection of data? Who will be able to see the information gathered?

While the study is designed to collect and assess the medical data of people with the MYBPC3 genetic mutation, no individual names or identifying information will be shared with the study sponsor as part of the study. The medical data of participants will be accessible only by the researchers, including the study sponsor, Tenaya Therapeutics, and its partners, contractors and agents.

What if I would like to withdraw from the study?

Participants can choose whether they want to take part in the study, and participants can change their mind at any time.

Study locations

The MyClimb study is being conducted in leading cardiovascular research centers in North America and Europe.

United States Locations

Arkansas Locations

Little Rock, Arkansas, United States, 72202

Recruiting

Arkansas Children's Hospital

California Locations

Los Angeles, California, United States, 90027

Recruiting

Children's Hospital Los Angeles

Sacramento, California, United States, 95817

Recruiting

University of California Davis Health

San Diego, California, United States, 92123

Recruiting

Rady Children's Hospital - San Diego

Colorado Locations

Aurora, Colorado, United States, 80045

Recruiting

University of Colorado Hospital - Anschutz Medical Campus

Delaware Locations

Wilmington, Delaware, United States, 19803

Recruiting

Nemours Alfred I. Dupont Hospital for Children

Florida Locations

Hollywood, Florida, United States, 33021

Recruiting

Joe DiMaggio Children's Hospital

Missouri Locations

Kansas City, Missouri, United States, 64108

Recruiting

Children's Mercy Hospital Kansas

Saint Louis, Missouri, United States, 63110

Recruiting

St. Louis Children's Hospital

New York Locations

Bronx, New York, United States, 10467

Recruiting

Montefiore Medical Center, Albert Einstein College of Medicine

Lake Success, New York, United States, 11042

Recruiting

Cohen Children's Medical Center

New York, New York, United States, 10029

Recruiting

Mount Sinai

New York, New York, United States, 10032

Recruiting

Columbia University Irving Medical Center

Ohio Locations

Cincinnati, Ohio, United States, 45229

Recruiting

Cincinnati Children's Hospital Medical Center

Cleveland, Ohio, United States, 44195

Recruiting

Cleveland Clinic Main Campus

Middlefield, Ohio, United States, 44062

Recruiting

DDC Clinic Center for Special Needs Children

Pennsylvania Locations

Lancaster, Pennsylvania, United States, 17601

Recruiting

Cardiology Care for Children

Philadelphia, Pennsylvania, United States, 19104

Recruiting

Children's Hospital of Philadelphia

Pittsburgh, Pennsylvania, United States, 15224

Recruiting

University of Pittsburgh Medical Center - Children's Hospital of Pittsburgh

Texas Locations

Dallas, Texas, United States, 75207

Recruiting

Children's Medical Center Dallas

Houston, Texas, United States, 77030

Recruiting

Texas Children's Hospital

Canada Locations

Alberta Locations

Edmonton, Alberta, Canada, T6G 2B7

Recruiting

University of Alberta Hospital

Ontario Locations

Toronto, Ontario, Canada,

Recruiting

The Hospital for Sick Children

Spain Locations

Barcelona, Spain, 8950

Recruiting

Hospital Sant Joan de Déu Barcelona

Madrid, Spain, 28003

Recruiting

Hospital General Universitario Gregorio Marañón

Vigo, Spain, 36312

Recruiting

Hospital Alvaro Cunqueiro - Clinico Universitario Vigo

United Kingdom Locations

Glasgow, United Kingdom, G12 0XH

Recruiting

NHS Greater Glasgow and Clyde

London, United Kingdom, SW3 6NP

Recruiting

Royal Brompton & Harefield NHS Foundation Trust

London, United Kingdom, WC1N 3JH

Recruiting

Great Ormond Street Hospital for Children NHS Foundation Trust

Scroll to see more locations

Participation information

For more information about the MyClimb study, please complete this form or contact clinical.trials@tenayathera.com or patient.advocacy@tenayathera.com.

For more information about the MyClimb study visit ClinicalTrials.gov and enter NCT05112237.

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Last Updated November 25, 2024